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CLDN12 - Humpath.com - Human pathology

Home > A. Molecular pathology > CLDN12

CLDN12

MIM.611232

Saturday 17 May 2008

Definition: Claudins (CLDNs), such as CLDN12, are components of epithelial cell tight junctions.

Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains.

Pathology

- amplified in esophageal adenocarcinoma

See also

- Claudins (CLDNs)