Wednesday 14 May 2008
Definition: CD38 is an ectoenzyme involved in transmembrane signaling and cell adhesion and is used as a disease marker for leukemias and myeloma.
- CD38 is a dependable negative prognostic marker for chronic lymphocytic leukemia (CLL).
- CD38 is a component of a complex network delivering growth and survival signals to CLL cells. In conjunction with chemokines and their receptors, CD38 also influences cell migratory responses.
Deaglio S, Aydin S, Vaisitti T, Bergui L, Malavasi F. CD38 at the junction between prognostic marker and therapeutic target. Trends Mol Med. 2008 May;14(5):210-8. PMID: 18403265