Wednesday 14 May 2008
Definition: CD38 is an ectoenzyme involved in transmembrane signaling and cell adhesion and is used as a disease marker for leukemias and myeloma.
- CD38 is a dependable negative prognostic marker for chronic lymphocytic leukemia (CLL).
- CD38 is a component of a complex network delivering growth and survival signals to CLL cells. In conjunction with chemokines and their receptors, CD38 also influences cell migratory responses.