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CD38

Wednesday 14 May 2008

CD38 is an ectoenzyme involved in transmembrane signaling and cell adhesion and is used as a disease marker for leukemias and myeloma.

CD38 is a dependable negative prognostic marker for chronic lymphocytic leukemia (CLL).

CD38 is a component of a complex network delivering growth and survival signals to CLL cells. In conjunction with chemokines and their receptors, CD38 also influences cell migratory responses.

References

- Deaglio S, Aydin S, Vaisitti T, Bergui L, Malavasi F. CD38 at the junction between prognostic marker and therapeutic target. Trends Mol Med. 2008 May;14(5):210-8. PMID: #18403265#