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MIM.607725 14q11.2

Tuesday 13 May 2008

Poly(ADP-ribose) polymerase-2 (PARP-2)

Definition: Poly(ADP-ribose) polymerase-2 (PARP2) belongs to a family of enzymes that catalyze poly(ADP-ribosyl)ation of proteins.

PARP1 (PARP-1) and PARP2 are so far the only PARPs enzymes whose catalytic activity has been shown to be induced by DNA-strand breaks, providing strong support for key shared functions in the cellular response to DNA damage.

PARP-2 has unique functions in specific processes, such as genome surveillance, spermatogenesis, adipogenesis and T cell development.

See also


  • PARP1