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S100s

Friday 24 October 2003

S-100, protein S-100, S100; S100

WKP

Definition : S100 proteins (S100s) is a heterogeneous fraction of dimeric polypeptides (alpha and beta subunits) that can exist in different combination forms within the various tissues. See also : S-100 (IHC marker)

The S100 proteins are a family of low-molecular-weight proteins found in vertebrates and characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand type") conformation. There are at least 21 different S100 proteins.

They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1 , S100A2 , S100A3. They are also considered as Damage-associated molecular pattern molecules (DAMPs) and knockdown of AHR downregulates the expression of S100 proteins in THP-1 cells.

Members

S100As S100A1 S100A2 S100A3 S100A4 S100A5 S100A6 S100A7
S100A8 S100A9 S100A10 S100A11 S100A12 S100A13 S100A14
S100B

See also