Friday 24 October 2003
CUtaneous histiocytoses are a heterogeneous group of disorders that are characterized by the proliferation and accumulation of reactive or neoplastic histiocytes.
Three classes of histiocytoses have been defined:
- class I, Langerhans cell histiocytosis;
- class II, non-Langerhans cell histiocytosis without features of malignancy;
- class III, malignant histiocytic proliferations.
Although the disorders in classes I and II usually have a benign appearance on histology and are commonly non-aggressive and self-healing, some can cause debilitating or even fatal outcomes.
congenital self-healing histiocytosis (CD1a-, S-100-) (1908575)
cutaneous langerhans histiocytosis
cutaneous juvenile xanthogranuloma
sinus histiocytosis with massive lymphadenopathy
regressing atypical histiocytosis
nonfamilial histiocytic dermatoarthritis and familial histiocytic dermatoarthritis
multiple widespread benign lesions
- xanthoma disseminatum
- generalized eruptive histiocytoma
- nodular non-X histiocytosis
- various xanthomatous eruptions associated with paraproteinemia
Ringel E, Moschella S. Primary histiocytic dermatoses. Arch Dermatol. 1985 Dec;121(12):1531-41. PMID: 2998286