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dendrocytes

Friday 24 October 2003

Dermal dendrocytes represent a population of resident cells of the dermis identified recently by virtue of the immunohistochemical expression of the coagulation factor XIIIa (fXIIIa).

These dendritic cells of bone-marrow origin bear particular histoenzymatic and immunohistochemical features, some of which are shared with antigen-presenting cells; however, they are clearly distinct from epidermal Langerhans cells (S100+, CD1a+).

Dermal dendrocytes could act as macrophages, antigen-presenting cells or participate in the homeostasis of macromolecules of the dermis.

These cells give rise to some cutaneous tumours and seem involved in inflammatory dermatoses where they act by means of cytokine production; they represent targets of HIV infection.

Immunophenotype

- factor XIIIa+
- fascin+
- CD34+

Pathology

- dendrocytic tumors (dendrocytic proliferations)

  • dermal dendrocyte hamartoma
  • dermal dendrocytoma

- dendritic cell-related histiocytoses

  • juvenile xanthogranuloma (#12717244#)
  • xanthoma disseminatum

See also

- cutaneous dendritic cells

  • cutaneous Langerhans cells

References

- Headington JT. The dermal dendrocyte. Adv Dermatol. 1986;1:159-71. PMID: #3079241#