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lipid-laden macrophages

Friday 24 October 2003

spumous macrophages, foamy macrophages, foam cells; lipid-laden histiocytes, foamy histiocytes

Digital cases (Digital slides)

- HPC:380 : Foamy macrophages in pulmonary alveoles.
- JRC:336 : Niemann-Pick’s disease (Spleen).

Definition: Macrophages that are laden with lipid (predominantly cholesterol), and that have differentiated from circulating monocytes.

Etiology (Exemples)

- xanthomatous tumors
- histiocytoses

  • Langerhans cell histiocytosis
  • non-Langerhans cell histiocytosis
    • juvenile xanthogranunloma
    • Erdheim-Chester disease

- inherited metabolic diseases

Localization

- renal foamy macrophages

  • glomerular intracapillary foamy macrophages
  • renal tubulary foamy macrophages

- medullary foamy macrophages

- lungs: lipid-laden macrophages in pulmonary alveoles

Portfolio

  • Foamy macrophages in renal tubules
  • Lipophages in alveolar lavage
  • Gaucher cell in bone marrow cytology
  • Gaucher cell in bone marrow cytology
  • Gaucher cell in bone marrow cytology
  • Gaucher cell in bone marrow cytology
  • Gaucher cell in bone marrow cytology