Humpath.com - Human pathology

Home > D. General pathology > Blood and immunity > sinus histiocytosis with massive lymphadenopathy

sinus histiocytosis with massive lymphadenopathy

Friday 24 October 2003

Sinus histiocytosis with massive lymphadenopathy is an idiopathic proliferation of unique histiocytes that have vesicular nuclei and voluminous pale cytoplasm, often with emperipolesis.

Associations

- Langerhans histiocytosis
- autoimmune lymphoproliferative syndrome (ALPS) (15958855)

Localization

- lymph nodes
- nasal fossae (8958550)
- retro-orbital space (8958550)
- skin

Immunohistochemistry

- CD68 +
- S-100 protein +
- CD1a -