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FUT4

MIM.104230 11q21

Tuesday 5 February 2008

FUT4 catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). It has been detected in human embryos (5-10 weeks) suggesting a role in development.

CD15 synthesis is directed by FUT9 (MIM.104230) in lymphoid cells and mature granulocytes and by FUT4 (MIM.606865) in promyelocytes and monocytes

CD15 is a carbohydrate adhesion molecule (not a protein) that mediates phagocytosis and chemotaxis.

Immunochemistry

- membranous labeling
- diffuse cytoplasmic or Golgi staining in classic Hodgkin lymphoma

Diagnosis

- Hodgkin lymphoma

  • Reed-Sternberg cells

- help differentiate between classic Hodgkin lymphoma (CD15+) and anaplastic large cell lymphoma (usually CD15-)
- help differentiate between adenocarcinoma (CD15+) and mesothelioma (CD15-)

Positive immunostaining

- Reed-Sternberg cells (classic Hodgkin’s lymphoma and follicular Hodgkin’s lymphoma)
- 15% of peripheral T cell lymphoma
- 50% of carcinomas
- 5% of B cell lymphomas

  • some B-CLL
  • some pre-pre B ALL
  • some AML
  • occasionally anaplastic large cell lymphoma (usually negative)

Negative immunostaining

- non-activated lymphocytes
- basophils
- platelets
- erythroid cells
- L& H cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)
- diffuse large B cell lymphoma
- granulocytic sarcoma
- systemic mastocytosis
- pleural epithelial mesothelioma
- hairy cell leukemia
- malignant meningioma
- malignant histiocytes
- Langerhans cell histiocytosis

See also

- CD15