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MIM.112210 11q13

Tuesday 5 February 2008

CD20, or MS4A1, is a human B-lymphocyte surface molecule that is widely expressed during B-cell ontogeny, from early pre-B-cell developmental stages until final differentiation into plasma cells.

Functional studies using monoclonal antibodies have shown that antibody binding to CD20 inhibits B-cell proliferation caused by mitogens and inhibits B-cell differentiation.

MS4A1 gene encodes a B-lymphocyte surface molecule (CD20) which plays a role in the development and differentiation of B-cells into plasma cells.

This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

MS4As family proteins

MS4A1 gene encodes a member of the membrane-spanning 4A gene family (MS4As).

MS4As family proteins share structural similarity, amino acid sequence homology, and chromosomal location. They contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions.

Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues.

See also

- CDs