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Chr.18 rearrangements

Friday 1 February 2008

Leukemias

- t(1;18)(q25;q23) 1q25 and 18q23 (no genes)
- t(1;18)(q10;q10) 1q10 and 18q10 (no genes)
- t(2;18)(p11;q21) (IGKC/BCL2) (IGKC at 2p11/BCL2 at 18q21)
- t(3;18)(q26;q11) EVI1 at 3q26.2 and 18q11

- der(9;18)(p10;q10) 9p10 and 18q10
- t(11;18)(q21;q21) BIRC3 at 11q21 and MALT1 at 18q21
- t(14;18)(q32;q21) IGH at 14q32 and BCL2 at 18q21
- t(18;21)(q21;q22) 18q21 and AML1 at 21q22
- t(18;22)(q21;q11) BCL2 at 18q21 and IGL at 22q11

Solid tumors

- t(X;18)(p11.2;q11.2) in synovial sarcoma (SYT/SSXs fusion gene) SSXs at Xp11.2 and SS18 (SYT) at 18q11.2

See also

- trisomy 18 (+18) in lymphoproliferative disorders