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tumoral aneuploidy

Thursday 31 January 2008

An abnormal chromosome number, a condition known as aneuploidy, is a common characteristic of tumor cells. Noting this correlation, Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis. However, this hypothesis has remained untested due to the difficulty of selectively generating aneuploidy in the absence of other defects.

See also

- tumorigenesis
- aneuploidy

Reviews

- Duesberg P, Li R, Fabarius A, Hehlmann R. Aneuploidy and cancer: from correlation to causation. Contrib Microbiol. 2006;13:16-44. PMID: #16627957#

- Cimini D, Degrassi F. Aneuploidy: a matter of bad connections. Trends Cell Biol. 2005 Aug;15(8):442-51. PMID: #16023855#

- Kops GJ, Weaver BA, Cleveland DW. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer. 2005 Oct;5(10):773-85. PMID: #16195750#

- Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature. 2004 Nov 18;432(7015):338-41. PMID: #15549096#

- Duesberg P, Fabarius A, Hehlmann R. Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells. IUBMB Life. 2004 Feb;56(2):65-81. PMID: #15085930#

- Matzke MA, Mette MF, Kanno T, Matzke AJ. Does the intrinsic instability of aneuploid genomes have a causal role in cancer ? Trends Genet. 2003 May ;19(5):253-6. PMID : #12711216#

- Duesberg PH. Are cancers dependent on oncogenes or on aneuploidy? Cancer Genet Cytogenet. 2003 May;143(1):89-91. PMID: #12742162#

- Duesberg P, Rasnick D. Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil Cytoskeleton. 2000 Oct;47(2):81-107. PMID: #11013390#

- Duesberg P, Li R, Rasnick D, Rausch C, Willer A, Kraemer A, Yerganian G, Hehlmann R. Aneuploidy precedes and segregates with chemical carcinogenesis. Cancer Genet Cytogenet. 2000 Jun;119(2):83-93. PMID: #10867141#

- Rasnick D, Duesberg PH. How aneuploidy affects metabolic control and causes cancer. Biochem J. 1999 Jun 15;340 ( Pt 3):621-30. PMID: #10359645#