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i(7q)

Tuesday 15 January 2008

Tumors

- hepatosplenic T-cell lymphoma (11807981)
- adult Wilms tumor (11117788)

In adult Wilms tumor

The characteristic findings of isochromosome 7q, lack of trisomy or tetrasomy for chromosome 12, and absence of persistent renal blastema suggest that the pathogenesis of Wilms’ tumors in adults may be different than in the pediatric population. These genetic features may be helpful in distinguishing adult Wilms’ tumors from other primary renal tumors. (11117788)

References

- Isochromosome 7q in adult Wilms’ tumors: diagnostic and pathogenetic implications. Rubin BP, Pins MR, Nielsen GP, Rosen S, Hsi BL, Fletcher JA, Renshaw AA. Am J Surg Pathol. 2000 Dec;24(12):1663-9. PMID: 11117788

- Wlodarska I, Martin-Garcia N, Achten R, De Wolf-Peeters C, Pauwels P, Tulliez M, de Mascarel A, Brière J, Patey M, Hagemeijer A, Gaulard P. Fluorescence in situ hybridization study of chromosome 7 aberrations in hepatosplenic T-cell lymphoma: isochromosome 7q as a common abnormality accumulating in forms with features of cytologic progression. Genes Chromosomes Cancer. 2002 Mar;33(3):243-51. PMID: 11807981