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sinonasal NK/T-cell lymphoma

Tuesday 15 January 2008

Extranodal NK/T-cell lymphoma, nasal type; Extranodal NK/T-cell Lymphoma, Nasal Type

Digital cases

- pathxchange.org #7926

Epidemiology

Sinonasal natural killer (NK)/T-cell lymphomas are common in Asia and areas of South and Central America but are rarely seen in North America and Europe.

Sinonasal NK/T-cell lymphomas in the United States most often occur in ethnic groups from areas of reported high frequency (Asia, Central and South America), although less commonly than in endemic populations, and are otherwise similar phenotypically.

Synopsis

- necrosis
- angiodestructive pattern
- extensive partially infarcted lymphomatous infiltration
- small, medium, and occasionally large lymphoid cells with medium sized nucleoli.
- The nucleoli are more prominent in the larger cells.
- Cytoplasm is copious and pale pink.

Immunochemistry

- CD3+
- TIA-1+
- CD45+
- granzyme B+

  • perforin +/-
  • CD56 (66%)
  • CD8 (20%)
  • EBV EBER-ISH (100%)
  • TCR-gamma gene rearrangement (7%)
  • CD16-
  • CD57-
  • CK-

See also

- sinonasal lymphomas

References

- Extranodal NK/T-cell Lymphoma, Nasal Type, Includes Cases of Natural Killer Cell and αβ, γδ, and αβ/γδ T-cell Origin: A Comprehensive Clinicopathologic and Phenotypic Study. Pongpruttipan T, Sukpanichnant S, Assanasen T, Wannakrairot P, Boonsakan P, Kanoksil W, Kayasut K, Mitarnun W, Khuhapinant A, Bunworasate U, Puavilai T, Bedavanija A, Garcia-Herrera A, Campo E, Cook JR, Choi J, Swerdlow SH. Am J Surg Pathol. 2012 Feb 3. PMID: #22314189#

- Gaal K, Sun NC, Hernandez AM, Arber DA. Sinonasal NK/T-cell lymphomas in the United States. Am J Surg Pathol. 2000 Nov;24(11):1511-7. PMID: 11075852

- Cuadra-Garcia I, Proulx GM, Wu CL, Wang CC, Pilch BZ, Harris NL, Ferry JA. Sinonasal lymphoma: a clinicopathologic analysis of 58 cases from the Massachusetts General Hospital. Am J Surg Pathol. 1999 Nov;23(11):1356-69. PMID: #10555004#