Tuesday 8 January 2008
The predicted 904-amino acid TLR3 protein contains the characteristic Toll motifs: an extracellular leucine-rich repeat (LRR) domain and a cytoplasmic interleukin-1 receptor-like region.
Toll receprors in Drosophila
In Drosophila, the Toll transmembrane receptor plays a central role in dorsal-ventral axis formation. In addition, the Toll pathway controls the induction of potent antimicrobial factors in the adult fly. This role in Drosophila immune defense has mechanistic parallels to the interleukin-1 pathways that govern a host of immune and inflammatory responses in vertebrates.
susceptibility to herpes simplex encephalitis
Zhang, S.-Y.; Jouanguy, E.; Ugolini, S.; Smahi, A.; Elain, G.; Romero, P.; Segal, D.; Sancho-Shimizu, V.; Lorenzo, L.; Puel, A.; Picard, C.; Chapgier, A.; and 21 others : TLR3 deficiency in patients with herpes simplex encephalitis. Science 14: 317:-1522-1527, 2007.