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Tuesday 1 January 2008

Smc5/6 coordinates DNA repair, in part through post-translational modification of uncharacterized target proteins that can dictate their subcellular localization, and that Smc5/6 also functions to establish DNA-damage-dependent cohesion.

A nucleolar-specific Smc5/6 function has been proposed because Smc5/6 yeast mutants display penetrant phenotypes of ribosomal DNA (rDNA) instability. rDNA repeats are replicated unidirectionally.

Another complex containing SMC5 and SMC6 (Smc5/6) is implicated in DNA repair and checkpoint responses.

See also

- SMCs


- Murray JM, Carr AM. Smc5/6: a link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol. 2007 Dec 5; PMID: 18059412