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protein transport

Monday 20 October 2003

Types

- vesicle-mediated protein transport

Pathology

- inherited diseases characterized by defects in intracellular protein transport

  • defects affecting the protein-sorting apparatus
    • inclusion-cell disease (mucolipidosis II)
    • Hermansky-Pudlak disease
    • Chediak-Higashi disease
  • defects in cytoskeletal proteins involved in membrane transport
    • Griscelli disease
  • defects in the machinery for the docking and fusion of transport vesicles

- miscellaneous

  • COH1 mutations in Cohen syndrome

See also

- vesicle-mediated protein transport

References

- Zimmermann R, Muller L, Wullich B. Protein transport into the endoplasmic reticulum: mechanisms and pathologies. Trends Mol Med. 2006 Dec;12(12):567-73. PMID: #17071140#

- Graham TR. Flippases and vesicle-mediated protein transport. Trends Cell Biol. 2004 Dec;14(12):670-7. PMID: #15564043#

- Brooksbank C. Protein trafficking. Made for export. Nat Rev Mol Cell Biol. 2001 Feb;2(2):84-5. PMID: #11252962#