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classic Hodgkin lymphoma

Friday 17 October 2003

cHL, classical Hodgkin’s disease, classical Hodgkin lymphoma


- Classical Hodgkin lymphoma, mixed cellularity

- PAX5 in classic Hodgkin lymphoma

Digital cases

- HPC:188 (HPC:188) : classical Hodgkin lymphoma
- HPC:234 : classical Hodgkin lymphoma
- HPC:292 : classical Hodgkin lymphoma, mixed cellularity type
- HPC:337 : classical Hodgkin lymphoma, mixed cellularity type
- HPC:351 : classical Hodgkin lymphoma, scleronodular type
- JRC:7378 : classical Hodgkin lymphoma, in bone marrow.
- JRC:7415 : classical Hodgkin lymphoma.
- JRC:7424 : classical Hodgkin lymphoma (nodular sclerosing).


- nodular sclerosing Hodgkin lymphoma
- mixed cellularity Hodgkin lymphoma
- lymphocyte rich classical Hodgkin lymphoma
- lymphocytic depleted Hodgkin lymphoma (lymphocyte depletion)

  • diffuse fibrose variant
  • reticular variant

Microscopical synopsis

- heterogenous population
- Sternberg cells
- Hodgkin cells


- interfollicular Hodgkin lymphoma (6859389)


- mantle cell lymphoma (14576485, 14657719)

Differential diagnosis

- nodular lymphocyte predominant Hodgkin lymphoma
- reactive lymphadenitis (3366442)


- t(l4;18)
- t(2;5)
- del(lp)
- dup(lq)
- del(6q)
- del(7q)
- Chr.4 rearrangments

  • 4q25-28 rearrangements


- Copy number alterations are found in more than 20% of cases included gains of 2p, 9p, 12p, 16p, 17p, 17q, 19p, 19q, 20q, 21q and losses of 1p, 6q, 7q, 8p, 11q, and 13q. (20339089)

- high-resolution recurrent changes defining minimally gained and lost regions harboring genes involved in NFkappaB signaling such as REL, IKBKB, CD40, and MAP3K14. (20339089)

- Gains of chromosome 16p11.2-13.3 are significantly more frequent in pretreatment and relapse biopsies of patients failing treatment and were associated with shortened disease-specific survival (p=0.028). (20339089)

- In the therapy-resistant HL cell line KMH2, genomic gains and overexpression of the multidrug resistance gene ABCC1 mapping to cytoband 16p13.11. (20339089)

- doxorubicin exposure to KMH2 induces ABCC1 expression and that siRNA silencing of ABCC1 sensitizes KMH2 cells to doxorubicin toxicity in-vitro, suggesting that overexpression of ABCC1 contributes to the drug resistance phenotype found in KMH2. (20339089)

Susceptibility loci

- 2p16.1 (REL) (21037568)
- 8q24.21 (21037568)
- 10p14 (GATA3) (21037568)

See also

- Hodgkin lymphomas

  • nodular lymphocyte predominant Hodgkin lymphoma


- A genome-wide association study of Hodgkin’s lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Enciso-Mora V, Broderick P, Ma Y, Jarrett RF, Hjalgrim H, Hemminki K, van den Berg A, Olver B, Lloyd A, Dobbins SE, Lightfoot T, van Leeuwen FE, Försti A, Diepstra A, Broeks A, Vijayakrishnan J, Shield L, Lake A, Montgomery D, Roman E, Engert A, von Strandmann EP, Reiners KS, Nolte IM, Smedby KE, Adami HO, Russell NS, Glimelius B, Hamilton-Dutoit S, de Bruin M, Ryder LP, Molin D, Sorensen KM, Chang ET, Taylor M, Cooke R, Hofstra R, Westers H, van Wezel T, van Eijk R, Ashworth A, Rostgaard K, Melbye M, Swerdlow AJ, Houlston RS. Nat Genet. 2010 Dec;42(12):1126-30. PMID: 21037568

- Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome. Steidl C, Telenius A, Shah SP, Farinha P, Barclay L, Boyle M, Connors JM, Horsman DE, Gascoyne RD. Blood. 2010 Mar 25. PMID: 20339089

- Hammerschmidt W, Sugden B. Epstein-Barr virus sustains Burkitt’s lymphomas and Hodgkin’s disease. Trends Mol Med. 2004 Jul;10(7):331-6. PMID: 15242681