Home > E. Pathology by systems > Endocrine system > Thyroid > consumptive hypothyroidism

consumptive hypothyroidism

Friday 26 October 2007

Consumptive hypothyroidism is due to a vascular tumor expressing type 3 iodothyronine deiodinase.

The inactivation rate of thyroid hormone by D3 in tumors, as vascular tumors, can stress the secretory capacity even of the TSH-stimulated normal adult thyroid gland.

References

- Balazs AE, Athanassaki I, Gunn SK, Tatevian N, Huang SA, Haymond MW, Karaviti LP. Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. Ann Clin Lab Sci. 2007 Summer;37(3):280-4. PMID: #17709695#

- Ruppe MD, Huang SA, Jan de Beur SM. Consumptive hypothyroidism caused by paraneoplastic production of type 3 iodothyronine deiodinase. Thyroid. 2005 Dec;15(12):1369-72. PMID: #16405410#

- Guven A, Aygun C, Ince H, Aydin M, Pinarli FG, Baysal K, Kucukoduk S. Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother. Horm Res. 2005;63(2):86-9. PMID: #15711094#

- Konrad D, Ellis G, Perlman K. Spontaneous regression of severe acquired infantile hypothyroidism associated with multiple liver hemangiomas. Pediatrics. 2003 Dec;112(6 Pt 1):1424-6. PMID: #14654623#

- Huang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewich HP, Mandel SJ, Larsen PR. A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab. 2002 Oct;87(10):4457-61. PMID: #12364418#