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gene expression

Thursday 16 October 2003

Definition: Gene expression is the process by which the coded information of a gene is converted into the structures present and operating in the cell.

Expressed genes include those that are transcribed into mRNA and then translated into protein and those that are transcribed into RNA but not translated into protein (e.g., transfer and ribosomal RNAs).

The degree of expression is called expressivity.

Gene expression databases

- MGED Society, Microarray Gene Expression Data Society
- BodyMap at University of Tokyo
- GEO (Gene Expression Omnibus)

In humans

- HuGEIndex.org

By organs

- Kidney development gene expression database ar UCSD, the University of California at San Diego

See also

- knock-down of proteic expression

Videos

- gene expression regulation

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References

- Komili S, Silver PA. Coupling and coordination in gene expression processes: a systems biology view. Nat Rev Genet. 2008 Jan;9(1):38-48. PMID: 18071322

- Rockman MV, Kruglyak L. Genetics of global gene expression. Nat Rev Genet. 2006 Nov;7(11):862-72. PMID: 17047685

- Yanai I, Korbel JO, Boue S, McWeeney SK, Bork P, Lercher MJ. Similar gene expression profiles do not imply similar tissue functions. Trends Genet. 2006 Mar;22(3):132-8. PMID: 16480787

- Kaern M, Elston TC, Blake WJ, Collins JJ. Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet. 2005 Jun;6(6):451-64. PMID: 15883588

- Bartel DP, Chen CZ. Opinion: Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet. 2004 May;5(5):396-400. PMID: 15143321