Friday 12 October 2007
- The ADH2 (ADH1B) Arg47His polymorphism (MIM.103720) has been associated with alcoholism in numerous studies of several populations in Asia and Europe.
- Data from South and Southeast Asia confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia. (17847010)
Li H, Mukherjee N, Soundararajan U, Tarnok Z, Barta C, Khaliq S, Mohyuddin A, Kajuna SL, Mehdi SQ, Kidd JR, Kidd KK. Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. Am J Hum Genet. 2007 Oct;81(4):842-6. PMID: 17847010