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thymic mucinous adenocarcinoma

Thursday 4 October 2007

Synopsis

- islands and strips of tumor cells floating in large pools of extracellular mucin
- numerous psammoma bodies

- dilated glands, cords
- small nests infiltrating the thymic cyst wall
- mucin production

Immunohistochemistry

- positive for cytokeratin (CK) 7
- negative for CD5

Associations

- thymic cyst with areas of transition from benign to dysplastic epithelium

Differential diagnosis

- malignant mediastinal tumors

References

- Ra SH, Fishbein MC, Baruch-Oren T, Shintaku P, Apple SK, Cameron RB, Lai CK. Mucinous adenocarcinomas of the thymus: report of 2 cases and review of the literature. Am J Surg Pathol. 2007 Sep;31(9):1330-6. PMID: 17721187