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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(11,16)(p11;p11)


Wednesday 26 September 2007


- low-grade fibromyxoid sarcomas (LGFMS)

Molecular biology

- t(11,16)(p11;p11) translocation creating FUS/CREB3L1 fusion gene.

NB: Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS/CREB3L2 or FUS-CREB3L1 fusions, respectively. The t(7;16)(q33;p11) translocation creating FUS/CREB3L2 fusion gene (12960807) (also found in hyalinizing spindle cell tumor with giant rosettes).


- Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchere-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marques B, Aubain Somerhausen Nde S, Keslair F, Pedeutour F, Coindre JM. Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group. Am J Surg Pathol. 2007 Sep;31(9):1387-402. PMID: 17721195