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del(9)(p21)

Wednesday 19 September 2007

Target genes

- CDKN2A/CDKN2B

Tumors

- acute lymphoblastic leukemia (ALL)
- various cancers

Pathology

Deletion of 9p21 is the most commonly reported chromosomal abnormality in pediatric acute lymphoblastic leukemia, and published data suggest that the maternal chromosome is preferentially deleted.

Preferential maternal deletion of 9p21 and reports of a differentially methylated region (DMR) and of parental effects in mice with lymphoma suggest there may be an unrecognized imprinted locus in this region.

References

- Weeks RJ, Morison IM. Detailed methylation analysis of CpG islands on human chromosome region 9p21. Genes Chromosomes Cancer. 2006 Apr;45(4):357-64. PMID: 16372313