Tuesday 18 September 2007
Common fragile sites (cFSs) are related to cancer development.
FRA16D localized in the tumor-suppressor gene WWOX that is altered by deletions or loss of heterozygosity (LOH) in many cancers.
Sbrana I, Veroni F, Nieri M, Puliti A, Barale R. Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer. Genes Chromosomes Cancer. 2006 May;45(5):429-36. PMID: #16419058#