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8p22-p23 LOH

Tuesday 18 September 2007

Tumors

- prostatic adenocarcinoma (16470536)

  • Allelic loss at 8p22-p23 was significantly more frequent in clinical prostate cancer (CPC) than in incidental prostate cancer and in pT4 CPC than in earlier-stage CPC. (16470536)
  • Deletion of 8p is an important event in both the initiation and metastasis of prostate cancer.
  • The extremely high frequency of LOH at 8p22-23.1 in high-grade tumors suggests the existence of a novel putative tumor-suppressor gene associated with the progression of prostate cancer.

References

- Lu W, Takahashi H, Furusato B, Maekawa S, Ikegami M, Sudo A, Egawa S, Hano H. Allelotyping analysis at chromosome arm 8p of high-grade prostatic intraepithelial neoplasia and incidental, latent, and clinical prostate cancers. Genes Chromosomes Cancer. 2006 May;45(5):509-15. PMID: 16470536