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3p12 LOH

Sunday 16 September 2007

Homozygous deletions or loss of heterozygosity (LOH) at human chromosome band 3p12 are consistent features of lung and other malignancies, suggesting the presence of a tumor suppressor gene(s) (TSG) at this location.

Target genes

- ROBO1 (or DUTT1 (Deleted in U Twenty Twenty), FLJ21882, SAX3)

  • ROBO1 (DUTT1), the human ortholog of the fly gene ROBO, has homology with NCAM proteins.
  • Extensive analyses of ROBO1 in lung cancer have not revealed any mutations, suggesting that another gene(s) at this location could be of importance in lung cancer initiation and progression.

References

- Angeloni D, ter Elst A, Wei MH, van der Veen AY, Braga EA, Klimov EA, Timmer T, Korobeinikova L, Lerman MI, Buys CH. Analysis of a new homozygous deletion in the tumor suppressor region at 3p12.3 reveals two novel intronic noncoding RNA genes. Genes Chromosomes Cancer. 2006 Jul;45(7):676-91.PMID: 16607615