Monday 10 September 2007
Abnormalities of chromosome arm 1q have frequently been reported in B-cell lymphomas and correlated with poor outcome.
Five genes mapped to this region (BCL9, MUC1, FCGR2B, IRTA1, and RTA2) have been shown to be deregulated by juxtaposition with the IG genes.
Other anomalies of the 1q21-22 region are not involved in translocations with the IG genes.
Unbalanced translocations resulting in trisomy 1q and involving breakpoints at 1q12-21 18% of hepatoblastoma (a malignant embryonal liver tumor that occurs almost exclusively in infants and very young children). (15981236)
Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21. Tomlinson GE, Douglass EC, Pollock BH, Finegold MJ, Schneider NR. Genes Chromosomes Cancer. 2005 Oct;44(2):177-84. PMID: 15981236
Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS. Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer. 2002 Dec;35(4):318-28. PMID: 12378526