Home > A. Molecular pathology > KIF14

KIF14

MIM.611279 1q32.1

Thursday 6 September 2007

KIF14 is a member of the kinesin superfamily of microtubule-associated motors (KIFs) that play important roles in intracellular transport and cell division.

Pathology

- located in 1q32.1 amplification (62%) (positively associated with 6p gain and maybe MYCN gain) (17099872)

- KIF14 (kinesin family member 14) is an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines.

- KIF14 overexpression is a negative predictor of grade and outcome in breast cancer. (16570270)

References

- Corson TW, Gallie BL. KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. Int J Cancer. 2006 Sep 1;119(5):1088-94. PMID: 16570270