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3p21.3 LOH

Monday 3 September 2007

The early and frequent occurrence of deletions at 3p21.3 in lung cancer has led to the consideration of this chromosomal region as a lung cancer (LUCA) critical region with tumor suppressor activity.


- pulmonary carcinomas
- neuroblastomas (14%) (17064406)

Target genes

- RASSF1A on 3p21.3 (17064406)

See also

- 3p LOH

  • 3p21 LOH


- Elst A, Hiemstra BE, van der Vlies P, Kamminga W, van der Veen AY, Davelaar I, Terpstra P, te Meerman GJ, Gerbens F, Kok K, Buys CH. Functional analysis of lung tumor suppressor activity at 3p21.3. Genes Chromosomes Cancer. 2006 Dec;45(12):1077-93. PMID: 16958100

- Lazcoz P, Munoz J, Nistal M, Pestana A, Encio I, Castresana JS. Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma. BMC Cancer. 2006 Oct 25;6:254. PMID: 17064406