Monday 3 September 2007
The early and frequent occurrence of deletions at 3p21.3 in lung cancer has led to the consideration of this chromosomal region as a lung cancer (LUCA) critical region with tumor suppressor activity.
neuroblastomas (14%) (17064406)
- 3p21 LOH
Elst A, Hiemstra BE, van der Vlies P, Kamminga W, van der Veen AY, Davelaar I, Terpstra P, te Meerman GJ, Gerbens F, Kok K, Buys CH. Functional analysis of lung tumor suppressor activity at 3p21.3. Genes Chromosomes Cancer. 2006 Dec;45(12):1077-93. PMID: 16958100