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nasopharyngeal carcinomas

Monday 3 September 2007

nasopharyngeal carcinoma

Types

- EBV-associated undifferentiated nasopharyngeal carcinoma ( UCNT )
- HPV-associated nasopharyngeal carcinoma

Examples

- HPV-associated nasopharyngeal carcinoma

Susceptibility

Researchers identify three new susceptibility loci for nasopharyngeal carcinoma in the genome-wide association study they’ve published in Nature Genetics. The team examined 464,328 autosomal SNPs in 1,583 cases and 1,894 controls, and found that TNFRSF19, MDS1-EVI1, and the CDKN2A-CDKN2B gene cluster were associated with NPC. "Our findings provide new insights into the pathogenesis of NPC," the authors write.

References

- A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Jin-Xin Bei, Yi Li, Wei-Hua Jia, Bing-Jian Feng, Gangqiao Zhou, Li-Zhen Chen,Qi-Sheng Feng, Hui-Qi Low, Hongxing Zhang, Fuchu He, E Shyong Tai, Tiebang Kang, Edison T Liu, Jianjun Liu & Yi-Xin Zeng. Nature Genetics (2010)

- Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW. Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma.
Genes Chromosomes Cancer. 2007 Feb;46(2):171-80. PMID: 17099870