Home > A. Molecular pathology > DLEC1

DLEC1

MIM.604050 3p22-p21.3

Monday 3 September 2007

The 3p22-p21.3 chromosomal segment is 1 of 3 regions on 3p that are commonly deleted in various carcinomas.

Pathology

- Silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis (17099870)

See also

- 3p21.3-p22 LOH

References

- Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW. Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma.
Genes Chromosomes Cancer. 2007 Feb;46(2):171-80. PMID: 17099870

- Daigo, Y.; Nishiwaki, T.; Kawasoe, T.; Tamari, M.; Tsuchiya, E.; Nakamura, Y. : Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. Cancer Res. 59: 1966-1972, 1999. PubMed ID : 10213508