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EWSR1-CREB1

Wednesday 29 August 2007

EWSR1/CREB1

Fusion gene fornation by translocation

CREB1 at 2q32-q34 and EWSR1 at 22q12

Tumors

- clear cell sarcoma ( soft parts melanoma ) (17000668)
- angiomatoid fibrous histiocytoma (AFH) (17724745)

See also

- CREBSs
- ATF1-FUS
- ATF1-EWSR1

References

- Antonescu CR, Nafa K, Segal NH, Dal Cin P, Ladanyi M. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma—association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res. 2006 Sep 15;12(18):5356-62. PMID: 17000668

- Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2007 Aug 20; PMID: 17724745