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actin assembly

Wednesday 15 October 2003

Actin polymerization often occurs at the plasma membrane to drive the protrusion of lamellipodia and filopodia at the leading edge of migrating cells.

A role for actin polymerization in another cellular process that involves the reshaping of the plasma membrane, namely endocytosis, has recently been established.

Pathology of actin polymerization

- Lowe syndrome (mutations in the OCRL1 gene, which encodes a phosphatidylinositol 4,5 bisphosphate 5-phosphatase) (12428211)

References

- Kaksonen M, Toret CP, Drubin DG. Harnessing actin dynamics for clathrin-mediated endocytosis. Nat Rev Mol Cell Biol. 2006 Jun;7(6):404-14. PMID: 16723976

- Huang TY, Dermardirossian C, Bokoch GM. Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol. 2006 Feb;18(1):26-31. PMID: 16337782

- Stradal TE, Scita G. Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol. 2006 Feb;18(1):4-10. PMID: 16343889

- Condeelis J. How is actin polymerization nucleated in vivo? Trends Cell Biol. 2001 Jul;11(7):288-93. PMID: 11413039

- Frischknecht F, Way M. Surfing pathogens and the lessons learned for actin polymerization. Trends Cell Biol. 2001 Jan ;11(1):30-38. PMID : 11146296