Home > A. Molecular pathology > NPM1-ALK


Monday 23 July 2007

By tumors

- anaplastic large cell lymphoma (ALCL)

  • In anaplastic large-cell lymphomas positive for anaplastic lymphoma kinase (ALK) protein, the ALK gene is most commonly fused to the NPM gene, and less commonly to TPM3, TFG, ATIC, and other rare genes.

- ALK-associated Spitz tumor (25602801)


- Li C, Takino H, Eimoto T, Ishida T, Inagaki A, Ueda R, Suzuki R, Yoshino T, Nakagawa A, Nakamura S, Inagaki H. Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma. Mod Pathol. 2007 Jun;20(6):648-55. PMID: 17464320


  • t(2;5)(p23;q35) creating NPM1/ALK fusion gene