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TGFBR3

Friday 13 January 2017

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Definition: Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight.

Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors (TGFBRs ).

Pathology

- Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in :

Open References

- Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor.
Antonescu CR, Zhang L, Nielsen GP, Rosenberg AE, Dal Cin P, Fletcher CD.
Genes Chromosomes Cancer. 2011 Oct;50(10):757-64. doi : 10.1002/gcc.20897
PMID: 21717526