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phenomics

Sunday 8 July 2007

Definition: Phenomics is the systematic study of phenotypes on a genome-wide scale, by integrating basic, clinical and information sciences.

Phenomics is a field of study concerned with the characterization of phenotypes (phenome), which are characteristics of organisms that arise via the interaction of the genome with the environment.

Phenomics is a word coined by Steven A. Garan, Director of the Aging Research Centre (ARC) at a guest lecture he gave at the University of Waterloo in 1996.

The term is used by Australian Phenomics Facility, where mice are bred to show the effects that different genes have on their development.

The Consortium for Neuropsychiatric Phenomics at UCLA was established under the aegis of the NIH Roadmap Initiative in 2007 to advance understanding of neuropsychiatric phenotypes (neuropsychiatric phenome) on a genome-wide scale.

Types

- neuropsychiatric phenomics
- tumoral phenomics or cancer phenomics

See also

- human phenome (human phenomics)

  • neuropsychiatric phenome (see CNP)

- cancer phenome (cancer phenomics)

Reviews

- Phenomics: the next challenge. Houle D, Govindaraju DR, Omholt S. Nat Rev Genet. 2010 Dec;11(12):855-66. PMID: 21085204

- Zbuk KM, Eng C. Cancer phenomics: RET and PTEN as illustrative model. Nat Rev Cancer. 2007 Jan;7(1):35-45. PMID: 17167516

- Freimer, N. and Sabatti, C. (2003). The human phenome project. Nature Genetics, 34, 15-21. PMID 12721547

- Scriver, C. R. (2004). "After the genome—the phenome?" J Inherit Metab Dis 27(3): 305-17.

- Bogue, M. A. and S. C. Grubb (2004). "The Mouse Phenome Project." Genetica 122(1): 71-4.

- Garan, S. A., et al (2003). "Phenomics: a new direction for the study of neuroendocrine aging", Experimental Gerontology, Vol 38 (1-2), 218.

References

- Phenomics: expanding the role of clinical evaluation in genomic studies. Lanktree MB, Hassell RG, Lahiry P, Hegele RA. J Investig Med. 2010 Jun;58(5):700-6. PMID: 20216460

- Systematic discovery of nonobvious human disease models through orthologous phenotypes. McGary KL, Park TJ, Woods JO, Cha HJ, Wallingford JB, Marcotte EM. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6544-9. PMID: 20308572

- Phenomics: the systematic study of phenotypes on a genome-wide scale. Bilder RM, Sabb FW, Cannon TD, London ED, Jentsch JD, Parker DS, Poldrack RA, Evans C, Freimer NB. Neuroscience. 2009 Nov 24;164(1):30-42. PMID: 19344640

- Identifying disease-causal genes using Semantic Web-based representation of integrated genomic and phenomic knowledge. Gudivada RC, Qu XA, Chen J, Jegga AG, Neumann EK, Aronow BJ. J Biomed Inform. 2008 Oct;41(5):717-29. PMID: 18755295

- Edgetic perturbation models of human inherited disorders. Zhong Q, Simonis N, Li QR, Charloteaux B, Heuze F, Klitgord N, Tam S, Yu H, Venkatesan K, Mou D, Swearingen V, Yildirim MA, Yan H, Dricot A, Szeto D, Lin C, Hao T, Fan C, Milstein S, Dupuy D, Brasseur R, Hill DE, Cusick ME, Vidal M. Mol Syst Biol. 2009;5:321. PMID: 19888216