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p53 family

Thursday 5 July 2007

The role of p53 as a tumour suppressor is generally attributed to its ability to stop the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis.

The relatives and evolutionary predecessors of p53 (TP53), p63 (TP73L) and p73 (TP573), share the tumour-suppressor activity of p53 to some extent, but also have essential functions in embryonic development and differentiation control.

These ancestral functions in differentiation control contribute to the tumour-suppressor activity that the p53 family is famous for.

Members

- p53 (TP53) (MIM.191170)
- p63 (TP73L) (MIM.603273)
- p73 (TP573) (MIM.601990)