Wednesday 27 June 2007
Common fragile sites (CFSs) are regions of chromosomal break that may play a role in oncogenesis. The most frequent alteration occurs at FRA3B, within the FHIT gene, at chromosomal region 3p14.
FRA3B localized in the tumor-suppressor gene FHIT that is altered by deletions or loss of heterozygosity (LOH) in many cancers.
Sbrana I, Veroni F, Nieri M, Puliti A, Barale R. Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer. Genes Chromosomes Cancer. 2006 May;45(5):429-36. PMID: #16419058#