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t(12;21)(p13;q22)

Tuesday 26 June 2007

The ETV6/RUNX1 fusion gene is created by the t(12;21)(p13;q22).

The t(12;21) is known to arise in utero. The postnatal latency period is protracted and additional mutations are most likely necessary for overt ALL.

Tumors

- B-cell precursor acute lymphoblastic leukemia (B-ALL)

References

- Forestier E, Andersen MK, Autio K, Blennow E, Borgstrom G, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Rosenquist R, Swolin B, Johansson B; Nordic Society of Pediatric Hematology and Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG). Cytogenetic patterns in ETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature. Genes Chromosomes Cancer. 2007 May;46(5):440-50. PMID: 17285576