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MALAT1

MIM.607924 11q13 HGNC:29665

Tuesday 26 June 2007

HCN, "hepcarcin", LINC00047, "long intergenic non-protein coding RNA 47", MALAT-1, "metastasis associated in lung adenocarcinoma transcript 1", NCRNA00047, NEAT2, "non-protein coding RNA 47", "nuclear enriched abundant transcript 2", "nuclear paraspeckle assembly transcript 2 (non-protein coding)", PRO1073; metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)

Molecular biology

- TFEB-MALAT1 fusion gene by t(6;11)(p21;q13)

  • MALAT1 is rearranged in renal tumors harboring the t(6;11)(p21;q13) translocation, and noncoding MALAT1 transcripts are overexpressed in a number of human carcinomas.

- MALAT1-MHLB1 fusion in mesenchymal hamartoma of the liver (MHL)(17311249)

  • MALAT1 gene at 11q13
  • MHLB1 locus at 19q13.4

- MALAT1-GLI1 fusion in tumors

References

- Rajaram V, Knezevich S, Bove KE, Perry A, Pfeifer JD. DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation. Genes Chromosomes Cancer. 2007 May;46(5):508-13. PMID: 17311249

- Davis, I. J.; Hsi, B.-L.; Arroyo, J. D.; Vargas, S. O.; Yeh, Y. A.; Motyckova, G.; Valencia, P.; Perez-Atayde, A. R.; Argani, P.; Ladanyi, M.; Fletcher, J. A.; Fisher, D. E. : Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc. Nat. Acad. Sci. 100: 6051-6056, 2003. PubMed ID : 12719541

- Ji, P.; Diederichs, S.; Wang, W.; Boing, S.; Metzger, R.; Schneider, P. M.; Tidow, N.; Brandt, B.; Buerger, H.; Bulk, E.; Thomas, M.; Berdel, W. E.; Serve, H.; Muller-Tidow, C. : MALAT-1, a novel noncoding RNA, and thymosin beta-4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22: 8031-8041, 2003. PubMed ID : 12970751

- Kuiper, R. P.; Schepens, M.; Thijssen, J.; van Asseldonk, M.; van den Berg, E.; Bridge, J.; Schuuring, E.; Schoenmakers, E. F. P. M.; van Kessel, A. G. : Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. Hum. Molec. Genet. 12: 1661-1669, 2003. PubMed ID : 12837690