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fusion gene

Thursday 21 June 2007

fusion proteins; fusion genes

Definition: Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis. In 2007, 358 gene fusions involving 337 different genes have been identified.

See list

An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas.

The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated.

However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity.

See also

- gene fusions in sarcomas
- gene fusions in leukemias and lymphomas
- gene fusions in carcinomas


- fusion genes involving tyrosine kinases
- fusion genes involving transcription factors

Common fusion gene in different tumors

- EWSR1/CREB1 fusion gene in

- ETV6/NTRK3 fusion gene in

  • congenital fibrosarcoma
  • cellular mesoblastic nephroma


- FusionCancer :

See also

- amplification of fusion genes
- fusion transcripts
- fusion proteins
- tumoral translocations

Open references

- TumorFusions: an integrative resource for cancer-associated transcript fusions. 2017. doi : 10.1093/nar/gkx1018

- FusionCancer: a database of cancer fusion genes derived from RNA-seq data. Wang Y, Wu N, Liu J, Wu Z, Dong D. Diagn Pathol. 2015 Jul 28;10:131. doi : 10.1186/s13000-015-0310-4 PMID: 26215638


- Mitelman F, Johansson B, Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007 Apr;7(4):233-45. PMID: 17361217


- Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2007 Aug 20; PMID: 17724745

- Antonescu CR, Nafa K, Segal NH, Dal Cin P, Ladanyi M. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma—association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res 2006; 12: 5356-5362. Medline 17000668

- Aman P. Fusion genes in solid tumors. Semin Cancer Biol. 1999 Aug;9(4):303-18. PMID: 10448117