Thursday 14 June 2007
Definition: ARID1A is a recently identified tumor suppressor that functions in chromatin remodeling.
ARID1A gene product is a 120-kD cytoplasmic protein expressed in various tissues including skeletal muscle, brain, and spleen.
1p36.11 LOH is observed in human cancers
- ARID1A could have a tumor suppressor role (#17492758#).
Inactivating mutations of ARID1A and loss of its expression most frequently occur in ovarian clear cell carcinoma, ovarian endometrioid carcinoma, and uterine endometrioid carcinoma. (#24076775#)
- Loss of ARID1A expression, presumably due to mutation, plays an important role in tumor progression of uterine endometrioid carcinoma. (#24076775#)
Loss of ARID1A Expression Correlates With Stages of Tumor Progression in Uterine Endometrioid Carcinoma. Mao TL, Ardighieri L, Ayhan A, Kuo KT, Wu CH, Wang TL, Shih IeM. Am J Surg Pathol. 2013 Sep;37(9):1342-8. doi:10.1097/PAS.0b013e3182889dc3 . PMID: #24076775#
Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas. Wiegand KC, Lee AF, Al-Agha OM, Chow C, Kalloger SE, Scott DW, Steidl C, Wiseman SM, Gascoyne RD, Gilks B, Huntsman DG. J Pathol. 2011 Jul;224(3):328-33. PMID: #21590771#
Huang J, Zhao YL, Li Y, Fletcher JA, Xiao S. Genomic and functional evidence for an ARID1A tumor suppressor role. Genes Chromosomes Cancer. 2007 May 10;46(8):745-750 PMID: #17492758#