Thursday 14 June 2007
Definition: ARID1A is a recently identified tumor suppressor that functions in chromatin remodeling.
ARID1A gene product is a 120-kD cytoplasmic protein expressed in various tissues including skeletal muscle, brain, and spleen.
1p36.11 LOH is observed in human cancers
- ARID1A could have a tumor suppressor role (17492758).
- Loss of ARID1A expression, presumably due to mutation, plays an important role in tumor progression of uterine endometrioid carcinoma. (24076775)
Loss of ARID1A Expression Correlates With Stages of Tumor Progression in Uterine Endometrioid Carcinoma. Mao TL, Ardighieri L, Ayhan A, Kuo KT, Wu CH, Wang TL, Shih IeM. Am J Surg Pathol. 2013 Sep;37(9):1342-8. doi : 10.1097/PAS.0b013e3182889dc3 PMID: 24076775
Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas. Wiegand KC, Lee AF, Al-Agha OM, Chow C, Kalloger SE, Scott DW, Steidl C, Wiseman SM, Gascoyne RD, Gilks B, Huntsman DG. J Pathol. 2011 Jul;224(3):328-33. PMID: 21590771