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CABLES1

MIM.609194 18q

Tuesday 5 June 2007

CDK5 and ABL enzyme substrate 1 (CABLES1) is a cyclin-dependent kinase (CDKs)-binding protein that plays a role in proliferation and/or differentiation.

Pathology

- Loss of Cables 1 expression is observed in many human cancers such as colon, lung and endometrial.

- Loss of nuclear Cables 1 expression was observed with high frequency in a limited sample set of ovarian carcinomas, although the exact mechanisms which suppress Cables 1 function in ovarian cancer remain unknown.

See also

- CDKs

References

- Dong, Q.; Kirley, S.; Rueda, B.; Zhao, C.; Zukerberg, L.; Oliva, E. : Loss of Cables, a novel gene on chromosome 18q, in ovarian cancer. Mod. Path. 16: 863-868, 2003.

- Zukerberg, L. R.; DeBernardo, R. L.; Kirley, S. D.; D’Apuzzo, M.; Lynch, M. P.; Littell, R. D.; Duska, L. R.; Boring, L.; Rueda, B. R. : Loss of Cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Cancer Res. 64: 202-208, 2004. PubMed ID : 14729625