Home > A. Molecular pathology > MAP3K1

MAP3K1

MIM.600982 Chr.5

Monday 28 May 2007

Definition: MAP3Ks, or MEK kinases, are serine/threonine kinases that occupie a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM.176730) and many growth factors.

Pathology

- variants in predisposition to breast cancer (mammary carcinomas)

  • common alleles at single nucleotide polymorphisms (SNPs) in MAP3K1 (rs889312) are associated with increased breast cancer risks in the general population. (#18355772#)

See also

- MAP3Ks

References

Portfolio

  • Signal-transduction pathway of the TrkA tyrosine kinase receptor.