Monday 28 May 2007
Definition: MAP3Ks, or MEK kinases, are serine/threonine kinases that occupie a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM.176730) and many growth factors.
variants in predisposition to breast cancer (mammary carcinomas)
- common alleles at single nucleotide polymorphisms (SNPs) in MAP3K1 (rs889312) are associated with increased breast cancer risks in the general population. (18355772)