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HMGA1

MIM.600701 6p21

Friday 29 February 2008

Pathology

- 6p21 (HMGA1) rearrangements (21.3%) in pulmonary chondroid hamartoma (14621194)

- 6p21 amplification

- HMGA1 is a master regulator of tumor progression in triple-negative breast cancer cells. (23658826)

Animal models

- Knockdown of HMGA1 inhibits human breast cancer cell growth and metastasis in immunodeficient mice. Di Cello F, Shin J, Harbom K, Brayton C. Biochem Biophys Res Commun. 2013 Apr 26;434(1):70-4. doi : 10.1016/j.bbrc.2013.03.064 PMID: 23545254

- Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice (16510570)

- Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (15924147)

See also

- HMGAs

References

- HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells. Shah SN, Cope L, Poh W, Belton A, Roy S, Talbot CC Jr, Sukumar S, Huso DL, Resar LM. PLoS One. 2013 May 2;8(5):e63419. doi : 10.1371/journal.pone.0063419 PMID: 23658826

- Floris G, Debiec-Rychter M, Wozniak A, Magrini E, Manfioletti G, De Wever I, Tallini G, Sciot R. Malignant ectomesenchymoma: genetic profile reflects rhabdomyosarcomatous differentiation. Diagn Mol Pathol. 2007 Dec;16(4):243-8. PMID: 18043289

- Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID: 11576996

- Wood, L. J.; Mukherjee, M.; Dolde, C. E.; Xu, Y.; Maher, J. F.; Bunton, T. E.; Williams, J. B.; Resar, L. M. S. : HMG-I/Y, a new c-Myc target gene and potential oncogene. Molec. Cell Biol. 20: 5490-5502, 2000. PubMed ID : 10891489

- Tallini G, Dal Cin P. HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors. Adv Anat Pathol. 1999 Sep;6(5):237-46. PMID: 10472377

- Kazmierczak B, Dal Cin P, Wanschura S, Borrmann L, Fusco A, Van den Berghe H, Bullerdiek J. HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors. Genes Chromosomes Cancer. 1998 Dec;23(4):279-85. PMID: 9824199