Tuesday 1 May 2007
Gain of chromosome 17 is the most prevalent genetic abnormality identified in neuroblastoma (NB). Distal 17q gain has prognostic significance in NB.
WSB1 enhances the prognostic prediction when combined with other current prognostic factors in NB. (16804916)
WSB1 copy number correlates with its expression level and that its high expression associates with good prognosis suggesting a possible role of this gene in the biology of favorable outcome NB. (16804916)
Chen QR, Bilke S, Wei JS, Greer BT, Steinberg SM, Westermann F, Schwab M, Khan J. Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma. Genes Chromosomes Cancer. 2006 Sep;45(9):856-62. PMID: 16804916