Home > A. Molecular pathology > MSR1

MSR1

MIM.153622 8p22

Monday 6 October 2003

Macrophage scavenger receptors (MSRs) were originally defined as molecules that bind and mediate endocytosis of oxidized or acetylated low-density lipoprotein (LDL) particles that can no longer interact with the conventional LDL receptor.

Macrophage scavenger receptors bind a variety of microbes in addition to modified LDL particles. Macrophage integrins, notably Mac-1 (CD11b/CD18), may also bind microbes for phagocytosis.

Pathology

- susceptibility to prostatic adenocarcinoma (12471593)

References

- Latil, A.; Lidereau, R. : Genetic aspects of prostate cancer. Virchows Arch. 432: 389-406, 1998. PubMed ID : 9645438

- Maier, C.; Herkommer, K.; Hoegel, J.; Vogel, W.; Paiss, T. : A genomewide linkage analysis for prostate cancer susceptibility genes in families from Germany. Europ. J. Hum. Genet. 13: 352-360, 2005. PubMed ID : 15536476

- Maier, C.; Vesovic, Z.; Bachmann, N.; Herkommer, K.; Braun, A. K.; Surowy, H. M.; Assum, G.; Paiss, T.; Vogel, W. : Germline mutations of the MSR1 gene in prostate cancer families from Germany. Hum. Mutat. 27: 98-102, 2006. PubMed ID : 16287155

- Matsumoto, A.; Naito, M.; Itakura, H.; Ikemoto, S.; Asaoka, H.; Hayakawa, I.; Kanamori, H.; Aburatani, H.; Takaku, F.; Suzuki, H.; Kobari, Y.; Miyai, T.; Takahashi, K.; Cohen, E. H.; Wydro, R.; Housman, D. E.; Kodama, T. : Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc. Nat. Acad. Sci. 87: 9133-9137, 1990. PubMed ID : 2251254

- Miller, D. C.; Zheng, S. L.; Dunn, R. L.; Sarma, A. V.; Montie, J. E.; Lange, E. M.; Meyers, D. A.; Xu, J.; Cooney, K. A. : Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. Cancer Res. 63: 3486-3489, 2003. PubMed ID : 12839931