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lobular cholestasis

Saturday 31 May 2003

Synopsis

- hepatocytic cholestasis

  • hepatocytic degeneration
  • hepatocytic giant cell transformation

- canalicular cholestasis
- cholestaic hepatocytic rosettes
- biliary infarcts

Etiology (exemples)

- bile salt transporter mutations

  • Byler disease
  • BRIC (benign recurrent intrahepatic cholestasis)

- mitochondriopathies

  • Navajo neurohepatopathy

- sepsis-associated cholestasis in systemic sepsis (bacteriemia, septicemia)
- inflammation-associated cholestasis
- sickle cell anemia
- drug hepatotoxicity

- extrahepatic lymphoma
- early large bile-duct obstruction
- hepatic allograft (liver allograft)

  • post-transplant bile-flow impairment
  • post-transplant rejection (liver allograft rejection)
    - drugs (drug-induced cholestasis)
  • contraceptive steroids

See also

- Cholestasis

  • intra-hepatic cholestasis
    • lobular cholestasis
      • hepatocytic cholestasis
      • canalicular cholestasis

Portfolio

  • Centrilobular cholestasis.
  • Cholestasis and apoptotic bodies
  • Sepsis-associated cholestasis