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KIF3A

Wednesday 21 March 2007

KIF3A is a classical member of the kinesin superfamily proteins (KIFs), ubiquitously expressed although predominantly in neural tissues, and which forms a heterotrimeric KIF3 complex with KIF3B or KIF3C and an associated protein, KAP3. KIF3A might be involved in mesodermal patterning and in turn neurogenesis.

Animal models

- kif3A knockout mice (10330409)

  • kif3A-/- embryos displayed severe developmental abnormalities characterized by neural tube degeneration and mesodermal and caudal dysgenesis.

- mouse mutants lacking the KIF3A subunit of kinesin-II (10220415)

- Kidney-specific inactivation of the KIF3A subunit of kinesin-II (12672950)

- Cre-loxP knockout of Kif3a with RHO-Cre (17065525)

References

- Lin, F.; Hiesberger T.; Cordes, K.; Sinclair, A. M.; Goldstein, L. S. B.; Somlo, S.; Igarashi, P. : Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc. Nat. Acad. Sci. 100: 5286-5291, 2003. PubMed ID : 12672950

- Marszalek, J. R.; Ruiz-Lozano, P.; Roberts, E.; Chien, K. R.; Goldstein, L. S. B. : Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Nat. Acad. Sci. 96: 5043-5048, 1999. PubMed ID : 10220415